TRANSLATION UK 2012
A meeting bringing together researchers in translational control and other aspects of mRNA metabolism.
Tuesday 3rd and Wednesday 4th of April at the University of Southampton
Programme and Abstracts
The programme and abstracts are available here. All delegates will be provided with a copy of the abstract book upon registration.
Meeting Programme
Tues 3rd April
Registration will be open from 11:00 in Life Sciences Building 85.
Check in at Highfield Hall available from 12:00.
Lunch available from 12:30 in EEE foyer, Building 32.
13:30-15:30 Welcome and Oral session 1: EEE lecture theatre
Regulation of translation by cis-acting mRNA sequences
Chair: Sarah Mohammad-Qureshi, University of Manchester
1) Identification of novel alternative translation initiation codons and their consequences for the human proteome
Mark Coldwell, University of Southampton
2) An upstream open reading frame in ERCC5 establishes resistance to cisplatin
Joanna Somers, University of Leicester
3) Identification of novel members of the 5'-TOP family of mRNAs and their regulation by mTORC1 signalling
Valentina Iadevaia, University of Southampton
4) Remodelling of a polypyrimidine tract binding protein-containing complex is required for IRES-mediated translation during apoptosis
Helen King, University of Leicester
5) Modulation of Rous Sarcoma Virus frameshifting efficiency and its effect on replication
Nerea Irigoyen, University of Cambridge
15:30-17:00 Poster session 1: B85 foyer and B85/2207
Odd numbered posters. Refreshments served in EEE foyer.
17:00-18:40 Oral session 2: EEE lecture theatre
microRNAs and their regulation
Chair: Matt Brook, University of Edinburgh
6) Translational repression is the primary and critical step for microRNA mediated regulation
Hedda Meijer, University of Leicester
7) 4E-T represses translation of bound mRNAs in a P-body-independent manner, in part by binding eIF4E, and enhances silencing of microRNA-target mRNAs
Anastasiia Kamenska, University of Cambridge
8) The role of miRNAs in the Stress Response
Kimberley Smith, Royal Veterinary College
9) Identification of microRNAs for use as diagnostic biomarkers
Sarah Newbury, University of Sussex
10) RIP chip SRM: a new combinatorial large scale approach identifies translationally regulated miRNA targets in C. elegans
André Gerber, University of Surrey
18.40-00:00 Evening Banquet: Staff Social Centre, Building 38
Hartley Lounge bar open from 18:30 - delegates can book in to Highfield Hall at this time (15 min walk away).
Dinner (Garden Court - Garden End) 20:00.
Hartley Lounge bar will be open until midnight.
Wed 4th April
Breakfast in Highfield Hall is served between 08:00 and 09:00, please check out by 09:00.
09:00-10:20 Oral session 3: EEE lecture theatre
Regulation of translation by initiation factor complexes
Chair: Noel Wortham, University of Southampton
11) eIF2B promotes dissociation of eIF2-eIF5 to facilitate guanine nucleotide exchange
Martin Jennings, University of Manchester
12) mTOR signaling is required for calicivirus replication
Azimah Abdul Wahab, University of Surrey
13) Targeting the human eIF4E dorsal site using peptide-mimetics
Catriona Smith, University of Warwick
14) Gene-specific translation regulation by PDCD4 and eIF4A1 in breast cancer
Angelika Modelska, University of Cambridge
10:20-10:40 Refreshments: EEE foyer
10:40-12:00 Oral session 4: EEE lecture theatre
Systems biology approaches to investigate gene expression
Chair: Mark Stoneley, University of Leicester
15) Codon usage, translational speed and protein yield: the dance of the ribosomes
Tobias von der Haar, University of Kent
16) The limitations of ribosome profiling
Thomas Jackson, University of Leicester
17) A genome-wide view of mammalian initiation codons
Richard Edwards, University of Southampton
18) Modelling and measuring of transcription, poly(A) metabolism and mRNA decay
Cornelia de Moor, University of Nottingham
12:00-13:30 Poster session 2: B85 foyer and B85/2207
Even numbered posters. Lunch will be served in EEE foyer.
13:30-15:00 Oral session 5: EEE lecture theatre
Translation in cellular physiology
Chair: Helen Newbery, University of Edinburgh
19) Modulation of Eukaryotic Initiation Factor 6 activity as a therapeutic tool in ribosome?based disease
Elisa Pesce, San Raffaele Scientific Institute, Milan
20) Investigating the role of protein synthesis in modulating the localised reorganisation of the actin cytoskeleton
Mark Willett, University of Sussex
21) C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome
Joanna Rorbach, University of Cambridge
22) Elongation Factor 2 Kinase plays a role in associative learning
Justin Kenney University of Southampton
Closing Remarks and Poster and Oral Prize presentations
The meeting is hosted in Buildings 85 (Life Sciences) and 32 (EEE) which are situated on the university's main Highfield Campus.
The accommodation is at Highfield Hall on the Avenue Campus, approximately 10-15 minutes walk away.
Free car parking will be available on both campuses. If you wish to avail of this, please inform us of the car model, colour and registration plate at least 10 days before the meeting.
If coming by train, alight at either Southampton Airport Parkway or Southampton Central Station. Both stations have taxi ranks, or you can take a UniLink bus to the Highfield Interchange.
Southampton Airport is also not far from the campus, with its own taxi facilities, and the Airport Parkway bus stop is only a few minutes walk from the exit.
Travelling by Car to Highfield Hall
We request that delegates travel to Highfield Hall and park there or the Avenue Campus car park for the duration of the conference. Limited parking is available closer to the campus for those who require it. Please contact tluk2012@soton.ac.uk to obtain a permit for the Hampton Car Park or download a permit for Highfield Hall/Avenue campus here. Directions are available here.
From the M3
- Follow signs for Southampton A33
- Keep following the A33 (Bassett Avenue), keep in left hand lane
- Go straight over the next two roundabouts
- Continue through traffic lights at a major intersection
- Turn left at next set of traffic lights into Highfield Avenue
- Turn 1st right into Nile Road, and Highfield Hall is directly in front of you at the end of the road*
From the M27
- Use Junction 5 (Southampton Airport/Eastleigh)
- If coming from the East, take the 1st exit off the roundabout; If coming from the West, the 4th exit
- Follow the A335 dual carriageway through 2 sets of traffic lights; at the 3rd set, the road divides
- Turn right onto Burgess Road (McDonald's will be on your left)
- Go through three sets of traffic lights (do not turn into University Road) then turn left at the major intersection onto The Avenue
- Turn left at next set of traffic lights into Highfield Avenue
- Turn 1st right into Nile Road, and Highfield Hall is directly in front of you at the end of the road*
From the City Centre
- Follow the signs for the A33 (M3 London/ Winchester) onto The Avenue
- Once on The Avenue continue straight through two sets of traffic lights
- At the third set of traffic lights, turn right into Highfield Avenue
- Turn 1st right into Nile Road, and Highfield Hall is directly in front of you at the end of the road*
*NOTE: There are only 2/3 parking spaces outside the main entrances to Highfield Hall. More parking is located at the rear of Highfield Hall. To access, turn right onto Heatherdeane Road, right into Karthoum Road and just before the junction, turn right into Wolfe House car park.
The meeting is hosted in Buildings 85 (Life Sciences) and 32 (EEE) which are situated on the university's main Highfield Campus. The accommodation is at Highfield Hall on the Avenue Campus, approximately 10-15 minutes walk away.
A map will be provided with the abstract book. Registration for the meeting will take place in Life Sciences Building 85, and will be open from 11.00 on Tuesday 3rd April. Check in at Highfield Hall will be available from 12.00 on Tuesday 3rd April. Lunch will be served from 12.30 in Building 32 (EEE) and the meeting will begin at 1.30 in the EEE lecture theatre 1015.
| TLUK2012 has been kindly sponsored by: |
For more information, please contact Dr Mark Coldwell or email tluk2012@soton.ac.uk.